Basic Information
| LncRNA/CircRNA Name | BLACAT1 |
| Synonyms | NA |
| Region | GRCh38_1:205434886-205437879 |
| Ensemble | ENSG00000281406 |
| Refseq | NR_103783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR etc. |
| Sample | glioma tissues and 23 corresponding adjacent normal tissues, Glioma cell lines (U87, U251MG, LN18, U118, T98G, and A172) andprimary normal human astrocytes (NHA) |
| Expression Pattern | up-regulated |
| Function Description | BLACAT1 levels were increased in glioma tissues. Upregulation of BLACAT1 showed poor prognosis. Silencing of BLACAT1 markedly repressed glioma proliferation, migration, and invasion, and suppressed glioma growth in vivo. We also illustrated that BLACAT1 worked as the sponge for miR-605-3p and promoted VASP expression. miR-605-3p was downregulated in glioma and repressed glioma proliferation, migration, and invasion. And VASP is upregulated and contributed to glioma progression. |
| Pubmed ID | 31093978 |
| Year | 2019 |
| Title | LncRNA BLACAT1 regulates VASP expression via binding to miR-605-3p and promotes giloma development |
External Links
| Links for BLACAT1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |