Basic Information
| LncRNA/CircRNA Name | RP11-284F21.9 |
| Synonyms | NA |
| Region | GRCh38_1:156637783-156641004 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | oral squamous cell carcinoma (OSCC) -derived cell lines Cal -27, Tca8113, SCC -9, and HB56, OSCC tissues and paracancerous tissues |
| Expression Pattern | up-regulated |
| Function Description | RP11 -284F21.9 was upregulated in human OSCC samples and cell lines. RP11 -284F21.9 depletion suppressed the proliferation, migration , and invasion of OSCC cell lines. There was interaction between RP11 -284F21.9, miR -383 -5p, and MAL2. Increased MAL2 and decreased miR -383 -5p expression were also detected in OSCC tissues and cell lines. In addition, RP11 -284F21.9 knockdown could reduce MAL2 expression, while miR -383 -5p inhibitors abolished this repressive effect.RP11-284F21.9 acted as a competing endogenous RNA (ceRNA) of miR-383-5p, leading to MAL2 upregulation, and subsequently promoted OSCC progression. |
| Pubmed ID | 31397491 |
| Year | 2019 |
| Title | RP11-284F21.9 Promotes Oral Squamous Cell Carcinoma Development via the miR-383-5p/MAL2 Axis |
External Links
| Links for RP11-284F21.9 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |