Basic Information
| LncRNA/CircRNA Name | BLACAT1 |
| Synonyms | NA |
| Region | GRCh38_1:205434886-205437879 |
| Ensemble | ENSG00000281406 |
| Refseq | NR_103783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | glioma tissues and adjacent non-tumor tissues ,normal human astrocyte(NHA) cells and glioma cell lines (U251, T98G, H4, A172 and LN229) |
| Expression Pattern | up-regulated |
| Function Description | BLACAT1 was overexpressed in glioma tissues and cell lines. High BLACAT1 expression was correlated with high tumor grade in glioma patients. Functional assays determined that BLACAT1 promoted glioma cell proliferation, migration, invasion and epithelial-mesenchymal transition in vitro. In addition, it was demonstrated that BLACAT1 activated the Wnt/?-catenin signaling pathway. |
| Pubmed ID | 31086604 |
| Year | 2019 |
| Title | Long Non-Coding RNA BLACAT1 Promotes the Proliferation and Invasion of Glioma Cells via Wnt/?-catenin Signaling |
External Links
| Links for BLACAT1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |