Basic Information
| LncRNA/CircRNA Name | RP11-190D6.2 |
| Synonyms | WWOX-AS1 |
| Region | GRCh38_16:78237362-78241218 |
| Ensemble | ENSG00000260969 |
| Refseq | XR_429776 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | EOC tissues, cell lines (HO8910-PM, SKOV3, HEY-A8, and OVCAR3) |
| Expression Pattern | down-regulated |
| Function Description | The RP11-190D6.2 expression was markedly downregulated in tumor tissues compared and EOC cell lines. We also found that RP11-190D6.2 was restored by 5-aza-2'-deoxycytidine treatment in EOC. In addition, the RP11-190D6.2 overexpression and knockdown experiments revealed that RP11-190D6.2 overexpression inhibited proliferation, migration, and invasion abilities in HO8910-PM cells. |
| Pubmed ID | 28280357 |
| Year | 2017 |
| Title | A new tumor suppressor lncRNA RP11-190D6.2 inhibits the proliferation, migration, and invasion of epithelial ovarian cancer cells. |
External Links
| Links for RP11-190D6.2 | GenBank HGNC NONCODE |
| Links for epithelial ovarian cancer | OMIM COSMIC |