Basic Information
| LncRNA/CircRNA Name | BLACAT1 |
| Synonyms | NA |
| Region | GRCh38_1:205434886-205437879 |
| Ensemble | ENSG00000281406 |
| Refseq | NR_103783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | head and neck squamous cell carcinoma |
| ICD-0-3 | C76.0 |
| Methods | qRT-PCR, Western blot |
| Sample | HNSCC tissues,cell lines (SCC25, FaDu, HN13, SCC4 and HN30) and one human immortalized normal mucosal cell line (DOK) |
| Expression Pattern | up-regulated |
| Function Description | BLACAT1 knockdown improved the radiosensitivity of HNSCC cells by changing cellular activities containing repressed cell viability, accelerated cell apoptosis, induced cell cycle arrest, and stimulated DNA damage response. BLACAT1 regulated the radiosensitivity of HNSCC cells by modulating PSEN1. |
| Pubmed ID | 31944856 |
| Year | 2020 |
| Title | Knockdown of lncRNA BLACAT1 Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinoma Cells by Regulating PSEN1 |
External Links
| Links for BLACAT1 | GenBank HGNC NONCODE |
| Links for head and neck squamous cell carcinoma | OMIM COSMIC |