Basic Information
| LncRNA/CircRNA Name | RP1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , Luciferase reporter assay , RIP , Western blot etc. |
| Sample | breast cancer tissues and matched adjacent normal tissues ,HEK-293T cells and breast cancer cells( MCF-7, T47D, SKBR3, MDA-MB-231, BT549, HCC38, and HCC1937?) |
| Expression Pattern | up-regulated |
| Function Description | RP1 was highly expressed in breast cancer and predicted poor prognosis of breast cancer patients.RP1 promoted the proliferation and metastasis of breast cancer cells in vitro and in vivo.RP1 maintained the EMT and stemness states of breast cancer cells via repressing p27kip1 protein expression.RP1 combined with the complex p-4E-BP1/eIF4E to prevent eIF4E from interacting with eIF4G, therefore attenuating the translational efficiency of p27kip1 mRNA.p27kip1 evidently downregulated Snail1 but not ZEB1 to inhibit invasion of breast cancer cells.KLF5 was positively correlated with RP1 in breast cancer tissues. Moreover, we demonstrated that KLF5 recruited p300 to the RP1 promoter to enhance RP1 expression. |
| Pubmed ID | 31073122 |
| Year | 2019 |
| Title | KLF5 Regulated lncRNA RP1 Promotes the Growth and Metastasis of Breast Cancer via Repressing p27kip1 Translation |
External Links
| Links for RP1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |