Basic Information
| LncRNA/CircRNA Name | ROR1-AS1 |
| Synonyms | ROR1 antisense RNA 1 |
| Region | GRCh38_1:64094442-64171297 |
| Ensemble | ENSG00000223949 |
| Refseq | NR_110665 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | RT-qPCR, Luciferase reporter gene assay |
| Sample | bladder tissues, bladder cancer cells (T24, 5637, J82, 253J and RT4) and a normal bladder epithelial cell (SV-HUC-1) |
| Expression Pattern | up-regulated |
| Function Description | ROR1-AS1 levels were obviously upregulated in bladder cancer tissues than matched normal bladder tissues. High expression of ROR1-AS1 was remarkably correlated with higher histological grade, advanced tumor stage, and positive lymph node metastasis. High ROR1-AS1 expression was markedly correlated with shorter overall survival of bladder cancer patients. Moreover, knockdown of ROR1-AS1 notably repressed T24 and 5637 cell growth and migration. ROR1-AS1 directly bound with miR-504 and act as a molecular sponge to decrease miR-504 expression. |
| Pubmed ID | 31929567 |
| Year | 2020 |
| Title | Upregulation of Long Non-Coding RNA ROR1-AS1 Promotes Cell Growth and Migration in Bladder Cancer by Regulation of miR-504 |
External Links
| Links for ROR1-AS1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |