Basic Information
| LncRNA/CircRNA Name | ROR1-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:64094442-64171297 |
| Ensemble | ENSG00000223949 |
| Refseq | NR_110665 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, RIP |
| Sample | colon cancer tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | ROR1-AS1 is highly expressed either in colon cancer tissues or in cell lines, which is able to enhance cell proliferation, accelerate cell cycle, and inhibit cell apoptosis. The mechanism of ROR1-AS1 to participate in the development of colon cancer may be the down-regulation of DUSP5 via combination with EZH2. |
| Pubmed ID | 32096171 |
| Year | 2020 |
| Title | LncRNA ROR1-AS1 promotes colon cancer cell proliferation by suppressing the expression of DUSP5/CDKN1A |
External Links
| Links for ROR1-AS1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |