Search Result

Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	renal cell carcinoma
ICD-0-3	C64.9
Methods	qPCR, Western blot, Luciferase reporter assay, etc.
Sample	RCC tissues, RCC cell lines Caki-1 and Caki-2, and normal human kidney cells HK-2
Expression Pattern	up-regulated
Function Description	ROR was found to be upregulated and microRNA (miR)-206 was found to be downregulated in RCC tissues and cells. Furthermore, the knockdown of ROR inhibited the proliferation, migration and invasion of RCC cells. It was found that ROR binds to miR 206, and that ROR induced cell proliferation and metastasis were reversed by the overexpression of miR 206. In addition, the levels of miR 206 and ROR were negatively correlated in RCC tissues. Furthermore, the overexpression of miR 206 notably suppressed the proliferation, migration and invasion of RCC cells, and these effects were enhanced by the knockdown of vascular endothelial growth factor (VEGF); cell growth and metastasis induced by miR 206 inhibitors could be reversed by the knockdown of VEGF. In addition, the expression levels of miR 206 and VEGF were inversely correlated in RCC samples. In summary, the results of the present study revealed that ROR was upregulated in RCC tissues, which promoted tumor progression by regulating the miR 206/VEGF axis.
Pubmed ID	31485634
Year	2019
Title	lncRNA ROR promotes the progression of renal cell carcinoma through the miR-206/VEGF axis

External Links