Basic Information
| LncRNA/CircRNA Name | LINC-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 |
| Ensemble | ENSG00000258609 |
| Refseq | NR_048536 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc |
| Sample | CRC tumor tissues and paired normal tissue, cell lines(NCM460, SW480, HT-29, HCT-116) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we found that LINC-RoR was upregulated in CRC cell lines and tissues. High expression of LINC-RoR was associated with poorer survival time and multivariate analysis results showed that LINC-RoR was an independent risk factor of tumor malignancy progression. Overexpression of LINC-RoR promoted the cell proliferation and knocked down it can reverse the effect in vitro. |
| Pubmed ID | 32273727 |
| Year | 2020 |
| Title | The Long Non-Coding RNA-RoR Promotes the Tumorigenesis of Human Colorectal Cancer by Targeting miR-6833-3p Through SMC4 |
External Links
| Links for LINC-ROR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |