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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	prostate cancer
ICD-0-3	C61.9
Methods	qPCR, Luciferase reporter assay, Western blot, etc.
Sample	52 pairs of prostate cancer tissue, adjacent normal prostate tissue. The prostate epithelial cell line (RWPE-1), human prostate cancer cell lines (LNCaP, DU145, PC-3).
Expression Pattern	up-regulated
Function Description	Our data revealed that RNCR3 functions as an tumor-promoting lncRNA in prostate cancer and may serve as a novel important biomarker for the diagnosis and treatment of prostate cancer. Upregulation of RNCR3 in prostate cancer cells compared with normal prostate epithelial cells RWPE-1. *P < 0.05. C. Kaplan-Meier survival curves for patients with prostate cancer tissues expressing low and high levels of RNCR3. We also confirmed that the oncogenic function of RNCR3 in prostate cancer are partly mediated by negative regulation of miR-185-5p targeted BRD8 ISO2. Moreover, knockdown of RNCR3 can also result to higher expression of IL-6, CCL2 and TNF-? in blood plasma, indicating that RNCR3 may have a biological function in immune system .
Pubmed ID	29887969
Year	2018
Title	Long non-coding RNA RNCR3 promotes prostate cancer progression through targeting miR-185-5p.

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