Basic Information
| LncRNA/CircRNA Name | RNCR3 |
| Synonyms | LINC00599 |
| Region | GRCh38_8:9900064-9905366 |
| Ensemble | ENSG00000253230 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | prostate cancer tissues, cell lines (LNCaP, DU145 and PC-3) |
| Expression Pattern | up-regulated |
| Function Description | RNCR3 expression was increased in prostate cancer compared to the corresponding adjacent normal prostate tissues. Moreover, our data showed that the increased expression of RNCR3 is significantly associated with tumor progression and poor survival of prostate cancer patients. Additionally, we found that RNCR3 knockdown could suppress the ability of proliferation, colony formation, and invasion of prostate cancer cells. Finally, we further confirmed that RNCR3 binds to miR-185-5p, which has been identified as a tumor suppressor in some human cancers, including prostate cancer. We also confirmed that the oncogenic function of RNCR3 in prostate cancer are partly mediated by negative regulation of miR-185-5p targeted BRD8 ISO2. |
| Pubmed ID | 29887969 |
| Year | 2018 |
| Title | Long Non-Coding RNA RNCR3 Promotes Prostate Cancer Progression Through Targeting miR-185-5p |
External Links
| Links for RNCR3 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |