Basic Information
| LncRNA/CircRNA Name | RMRP |
| Synonyms | RMRP, CHH, NME1, RMRPR, RRP2 |
| Region | GRCh38_9:35657751-35658018 |
| Ensemble | ENSG00000269900 |
| Refseq | NR_003051 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Cell transfection, Western blot etc. |
| Sample | LUAD tissues, cell lines (A549, SPC-A1, H1299 and H23) |
| Expression Pattern | up-regulated |
| Function Description | RMRP expression was upregulated in 25 cases compared to the adjacent normal tissues. We also showed that RMRP expression was upregulated in lung adenocarcinoma cell lines compared to the bronchial epithelial cell line. Ectopic expression of RMRP promoted lung adenocarcinoma cell proliferation, colony formation and invasion. In addition, overexpression of RMRP inhibited the miR-206 expression in the H1299 cell and increased the KRAS, FMNL2 and SOX9 expression, which were the target genes of miR-206. Re-expression of miR-206 reversed the RMRP-induced the H1299 cell proliferation and migration. |
| Pubmed ID | 27906963 |
| Year | 2016 |
| Title | LncRNA-RMRP Acts as an Oncogene in Lung Cancer. |
External Links
| Links for RMRP | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |