Basic Information
| LncRNA/CircRNA Name | RMRP |
| Synonyms | RMRP, CHH, NME1, RMRPR, RRP2 |
| Region | GRCh38_9:35657751-35658018 |
| Ensemble | ENSG00000269900 |
| Refseq | NR_003051 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Flow cytometry assay etc. |
| Sample | blood |
| Expression Pattern | up-regulated |
| Function Description | RMRP levels in tissue, plasma and gastric juices from patients with gastric cancer were significantly different from those from controls. Its levels were significantly associated with Borrmann type and metastasis. Plasma and gastric juice RMRP had higher sensitivity and specificity than commonly used markers (such as carcinoembryonic antigen and carbohydrate antigen 19-9). Knockdown of RMRP significantly inhibited cell proliferation in vitro and in vivo, whereas overexpression of RMRP promoted cell growth. Acting as a miR-206 sponge, RMRP modulated cell cycle by regulating Cyclin D2 expression. |
| Pubmed ID | 27192121 |
| Year | 2016 |
| Title | LncRNA-RMRP promotes carcinogenesis by acting as a miR-206 sponge and is used as a novel biomarker for gastric cancer. |
External Links
| Links for RMRP | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |