Basic Information
| LncRNA/CircRNA Name | RMRP |
| Synonyms | RMRP, CHH, NME1, RMRPR, RRP2 |
| Region | GRCh38_9:35657751-35658018 |
| Ensemble | ENSG00000277027 |
| Refseq | NR_003051 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | multiple myeloma |
| ICD-0-3 | C42.1 |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | Bone marrow and MM cell lines (NCI-H929 and RPMI-8226) |
| Expression Pattern | up-regulated |
| Function Description | High RMRP expression significantly correlated with worse disease-free survival and overall survival in MM patients. c-Myc promoted RMRP transcription by directly binding to its promoter region. Knockdown of RMRP inhibited proliferation and promoted apoptosis of OPM2 and RPMI-8226 cells. Negative correlation between RMRP, and miR-34a-5p was discovered in bone marrows of MM patients. c-Myc expression was inversely correlated with miR-34a-5p in bone marrows of MM patients. Additionally, silencing of RMRP led to a marked reduction in c-Myc expression in OPM2 and RPMI-8226 cells, and this action was obviously blocked by miR-34a-5p knockdown. Moreover, upregulation of miR-34a-5p repressed proliferation and promoted apoptosis of OPM2 and RPMI-8226 cells. |
| Pubmed ID | 30389523 |
| Year | 2019 |
| Title | c-Myc, RMRP, and miR-34a-5p form a positive-feedback loop to regulate cell proliferation and apoptosis in multiple myeloma. |
External Links
| Links for RMRP | GenBank HGNC NONCODE |
| Links for multiple myeloma | OMIM COSMIC |