Basic Information
| LncRNA/CircRNA Name | RMRP |
| Synonyms | NA |
| Region | GRCh38_9:35657751-35658018 |
| Ensemble | ENSG00000277027 |
| Refseq | NR_003051 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | HCC tissues and matched normal tissues ,cell lines(HL-7702, SMMC-7721, Bel-7402, MHCC-97, HepG2, Hep3B,or Huh-7) |
| Expression Pattern | up-regulated |
| Function Description | The high expression level of RMRP was correlated with poor prognosis in patients with HCC. RMRP knockdown suppressed HCC cell proliferation, invasion, and migration. miRNA-206 overexpression had similar effects in HCC cell lines. RMRP downregulation significantly suppressed TACR1/Erk1/2 pathway, while miRNA-206 was significantly upregulated (P < .05). RMRP downregulation inhibits HCC-related biological activities by the regulation of miRNA-206/TACR1. |
| Pubmed ID | 31579977 |
| Year | 2019 |
| Title | lncRNA RMRP Knockdown Suppress Hepatocellular Carcinoma Biological Activities via Regulation miRNA-206/TACR1 |
External Links
| Links for RMRP | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |