Basic Information
| LncRNA/CircRNA Name | RHPN1-AS1 |
| Synonyms | NA |
| Region | GRCh38_8:143366631-143368548 |
| Ensemble | ENSG00000254389 |
| Refseq | NR_026785 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | human breast cancer tissues and matched adjacent nontumor mammary tissues ,human breast cancer cell line MCF-7 |
| Expression Pattern | up-regulated |
| Function Description | Higher expression levels of RHPN1-AS1 in human breast cancer tissues and cell line MCF-7.RHPN1-AS1 was also located in MCF-7 cells.Knockdown of RHPN1-AS1 inhibited MCF-7 cell proliferation indicated , and the knockdown of RHPN1-AS1 enhanced P53 protein expression in MCF-7 and MDA-MB-231 cells.In addition, RHPN1-AS1 is a molecular sponge of miR-4261, and direct transcriptional target of c-Myc.RHPN1-AS1 exerts tumorigenesis by regulating P53 expression via MDM2 gene. |
| Pubmed ID | 31089812 |
| Year | 2019 |
| Title | c-Myc Induced the Regulation of Long Non-Coding RNA RHPN1-AS1 on Breast Cancer Cell Proliferation via Inhibiting P53 |
External Links
| Links for RHPN1-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |