Basic Information
| LncRNA/CircRNA Name | RGMB-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:98769618-98773469 |
| Ensemble | ENSG00000246763 |
| Refseq | NR_033932 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blot |
| Sample | hepatocellular carcinoma tissue, hepatocellular carcinoma cell lines (QGY-7703, HuH7, BEL-7402 and HepG2) |
| Expression Pattern | down-regulated |
| Function Description | lncRNA RGMB-AS1 was low-expressed in hepatocellular carcinoma tissues and cell lines, and associated with clinical stage, tumor size and metastasis. Survival analysis indicated that lncRNA RGMB-AS1 high was an independent favorable prognostic factor for hepatocellular carcinoma patients. Gain-of-function studies showed up-regulated lncRNA RGMB-AS1 expression suppressed hepatocellular carcinoma cells proliferation, migration and invasion, and promoted cells apoptosis. There was a positively association between lncRNA RGMB-AS1 and RGMB in hepatocellular carcinoma tissues, and up-regulated lncRNA RGMB-AS1 expression increased RGMB mRNA and protein expressions in hepatocellular carcinoma cells. |
| Pubmed ID | 29288973 |
| Year | 2017 |
| Title | The clinical significance and biological function of lncRNA RGMB-AS1 in hepatocellular carcinoma. |
External Links
| Links for RGMB-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |