Basic Information
LncRNA/CircRNA Name | RGMB-AS1 |
Synonyms | NA |
Region | GRCh38_5:98769618-98773469 |
Ensemble | ENSG00000246763 |
Refseq | NR_033932 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | laryngeal squamous cell cancer |
ICD-0-3 | C32.3 |
Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
Sample | LSCC tissues and adjacent non-tumor tissues |
Expression Pattern | up-regulated |
Function Description | lncRNA RGMB-AS1 was shown to be upregulated in LSCC tissues. High RGMB-AS1 expression was closely associated with advanced clinical features and poor prognosis. Silencing of lncRNA RGMB-AS1 suppressed LSCC cells proliferation and invasion in vitro and inhibited tumor growth in vivo. In mechanism, lncRNA RGMB-AS1 could sponge miR-22 to upregulate the expression of NLRP3. Additionally, we verified that the suppression of LSCC progression induced by lncRNA RGMB-AS1 reduction required the activity of miR-22. |
Pubmed ID | 31351424 |
Year | 2019 |
Title | LncRNA RGMB-AS1 promotes laryngeal squamous cell carcinoma cells progression via sponging miR-22/NLRP3 axis |
External Links
Links for RGMB-AS1 | GenBank HGNC NONCODE |
Links for laryngeal squamous cell cancer | OMIM COSMIC |