Basic Information
| LncRNA/CircRNA Name | PVT1-5 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
| Regulatory Mechanism | Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Information of Cancer
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | lung cancer tissues, lung cancer cell lines (A549, H226, H1299 and H446) |
| Expression Pattern | up-regulated |
| Function Description | PVT1-5 expression was significantly increased in lung cancer tissues and cell lines.miR-126 was associated with lncRNA-PVT1-5. Furthermore, knockdown of lncRNA-PVT1-5 in cells could down-regulate the expression of SLC7A5, the target of oncogenic miR-126, resulting in the cell proliferation. Conversely, inhibiting the expression of miR-126 markedly increased the expression of SLC7A5 and alleviated cell proliferation inhibition. |
| Pubmed ID | 29277611 |
| Year | 2017 |
| Title | Long non-coding RNA PVT1-5 promotes cell proliferation by regulating miR-126/SLC7A5 axis in lung cancer. |
External Links
| Links for PVT1-5 | GenBank HGNC Noncode |
| Links for lung cancer | Omim Cosmic |