Basic Information
| LncRNA/CircRNA Name | RAMS11 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | topoisomerase inhibitors | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RNA-seq, qPCR, Western blot etc. |
| Sample | CRC patient tissues,cell lines (CCD18-Co and SW480) |
| Expression Pattern | up-regulated |
| Function Description | RAMS11 is upregulated in mCRC. RAMS11 due to its association with poor disease-free survival and promotion of aggressive phenotypes in vitro and in vivo. RAMS11-dependent recruitment of Chromobox protein 4 (CBX4) transcriptionally activates Topoisomerase II alpha (TOP2?). |
| Pubmed ID | 32358485 |
| Year | 2020 |
| Title | Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression. |
External Links
| Links for RAMS11 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |