Basic Information
| LncRNA/CircRNA Name | RAMP2-AS1 |
| Synonyms | RAMP2-AS1 |
| Region | GRCh38_17:42753914-42761257 |
| Ensemble | ENSG00000197291 |
| Refseq | NR_024461 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, Western blot, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | glioblastoma tissues, cell lines (U87 and U251) |
| Expression Pattern | down-regulated |
| Function Description | lncRNA RAMP2-AS1 had significant decrease of expression in glioblastoma tissues and showed coexpressional relationship with NOTCH3, an important tumor promoter in many neoplastic diseases. Our follow up experiment indicated that (i) an overexpression of RAMP2-AS1 reduced glioblastoma cell proliferation in vitro and also reduced glioblastoma xenograft tumors in vivo; (ii) NOTCH3 and RAMP2-AS1 coexpression rescued the inhibitory action of RAMP2-AS1 in glioblastoma cells; and (iii) RNA pull-down assay revealed a direct interaction of RAMP2-AS1 with DHC10, which may consequently inhibit, as we hypothesize, the expression of NOTCH3 and its downstream signaling molecule HES1 in glioblastoma. |
| Pubmed ID | 27784795 |
| Year | 2016 |
| Title | The Potential Roles of Long Noncoding RNAs (lncRNA) in Glioblastoma Development. |
External Links
| Links for RAMP2-AS1 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |