Basic Information
| LncRNA/CircRNA Name | RAB11B-AS1 |
| Synonyms | NA |
| Region | GRCh38_19:8374373-8390685 |
| Ensemble | ENSG00000269386 |
| Refseq | NR_038237 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, etc. |
| Sample | osteosarcoma tissues, cell lines (U2OS, Sao-2, MG-63, MNNG/HOS Cl#5[R-1059-D]) |
| Expression Pattern | down-regulated |
| Function Description | Here we discovered a novel lncRNA, RAB11B antisense RNA (RAB11B-AS1), which is markedly down-regulated in human osteosarcoma (OS) and associated with OS metastasis and poor prognosis. We find that reduction of RAB11B-AS1 significantly facilitates proliferation, migration and invasiveness and prevents apoptosis of OS cells and results in lower sensitivity to cisplatin in these cells.These data suggest that DNA hyper-methylation in the promoter region of lnc-RAB11B-AS1 might play an important role in down-regulation of lnc-RAB11B-AS1 in osteosarcoma. |
| Pubmed ID | 29928484 |
| Year | 2018 |
| Title | Long non-coding RNA RAB11B-AS1 prevents osteosarcoma development and progression via its natural antisense transcript RAB11B. |
External Links
| Links for RAB11B-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |