Basic Information
| LncRNA/CircRNA Name | RAB11B-AS1 |
| Synonyms | NA |
| Region | GRCh38_19:8374373-8390685 |
| Ensemble | ENSG00000269386 |
| Refseq | NR_038237 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-qPCR, RNA-seq, Luciferase reporter assay |
| Sample | MDA-MB-231 , MDA-MB-468 , SUM159, MCF-7, T47D, BT474, ZR-75-1, HCC1954, HeLa, HEK293FT, and HEK293T cells |
| Expression Pattern | up-regulated |
| Function Description | a novel HIF-2 target lncRNA RAB11B-AS1 in breast cancer cells. RAB11B-AS1 is induced by hypoxia and in turn increases the expression of angiogenic factors including VEGFA and ANGPTL4 in hypoxic breast cancer cells through the recruitment of RNA Pol II, leading to tumor angiogenesis and metastasis. |
| Pubmed ID | 31900259 |
| Year | 2020 |
| Title | HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis |
External Links
| Links for RAB11B-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |