Basic Information
| LncRNA/CircRNA Name | PXN-AS1-L |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR , Luciferase reporter assay , Western blot etc. |
| Sample | NPC tissues and noncancerous NP tissues,Immortalized human normal NP epithelium cell line NP69 ,NPC cell lines(SUNE1, CNE1, CNE2, HONE1, and HNE1) |
| Expression Pattern | up-regulated |
| Function Description | PXN-AS1-L is upregulated in NPC tissues and cell lines. Increased expression of PXN-AS1-L predicts worse prognosis of NPC patients. PXN-AS1-L overexpression promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1-L silencing suppresses NPC cell proliferation, migration, and invasion in vitro.Mechanistically, PXN-AS1-L directly interacts with SAPCD2 mRNA 3'-untranslated region, prevents the binding of microRNAs-AGO silencing complex to SAPCD2 mRNA, and upregulates the mRNA and protein level of SAPCD2. |
| Pubmed ID | 31173488 |
| Year | 2019 |
| Title | Long Noncoding RNA PXN-AS1-L Promotes the Malignancy of Nasopharyngeal Carcinoma Cells via Upregulation of SAPCD2 |
External Links
| Links for PXN-AS1-L | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |