Basic Information
| LncRNA/CircRNA Name | PWRN1 |
| Synonyms | NA |
| Region | GRCh38_15:24493137-24652130 |
| Ensemble | ENSG00000259905 |
| Refseq | NR_026646 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qPCR, Western blot, RIP, Luciferase reporter assay |
| Sample | cell line (HEK-293, GES-1, MGC-803, HGC-27, SGC-7901, MKN-45), GC tissues |
| Expression Pattern | up-regulated |
| Function Description | PWRN1 affected PTEN/Akt/MDM2/p53 axis via suppressing miR-425-5p.PWRN1 up-regulated could reduce proliferation and metastasis and increased apoptosis in GC cells, while miR-425-5p had reverse effects. PWRN1 may target an oncogene miR-425-5p. |
| Pubmed ID | 29535266 |
| Year | 2018 |
| Title | Prader-Willi region non-protein coding RNA 1 suppressed gastric cancer growth as a competing endogenous RNA of microRNA-425-5p. |
External Links
| Links for PWRN1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |