Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | gastric cancer tissues, cell lines (BGC823, SGC7901 etc.) |
| Expression Pattern | up-regulated |
| Function Description | PVT-1 was highly expressed in gastric cancer tissues of cisplatin-resistant patients and cisplatin-resistant cells.Overexpression of LncRNA PVT1 in gastric carcinoma promotes the development of MDR,suggesting an eficacious target for reversing MDR in gastric cancer therapy. |
| Pubmed ID | 25956062 |
| Year | 2015 |
| Title | Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |