Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay etc. |
| Sample | gastric cancer tissues, cell lines (SGC7901 and BGC823) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 was up-regulated in GC tissues. MiR-152 was negatively associated with PVT1 expression in GC tissues. We found that PVT1 have three binding sequences for miR-152. Moreover, PVT1 might inhibit the expression of miR-152 and increased the expression of CD151 and FGF2 through regulating miR-152. PVT1 was positively associated with CD151 and FGF2 expression in GC tissues. |
| Pubmed ID | 28258379 |
| Year | 2017 |
| Title | Long Noncoding RNA PVT1 Acts as a Sponge to Inhibit microRNA-152 in Gastric Cancer Cells. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |