Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, RIP |
| Sample | hepatocellular carcinoma tissues, cell lines (SMCC-7721, Huh-7 and SK-hep-1,LO2) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 was increased in HCC tissues and higher PVT1 expression was associated with tumor size, histological differentiation grade and advanced TNM stage. PVT1 promoted cell proliferation and invasion in HCC.PVT1 significantly inhibited miR-214 expression by interacting with enhancer of zeste homolog 2 (EZH2).PVT1/EZH2/miR-214 regulatory pathway might serve as new target for HCC treatment. |
| Pubmed ID | 28800314 |
| Year | 2017 |
| Title | Long noncoding RNA PVT1 promotes hepatocellular carcinoma progression through regulating miR-214. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |