Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot |
| Sample | NSCLC tissues, cell lines (A549 and SPCA-1) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 was overexpressed in the hypoxic lung cancer cells.PVT1 functioned as competing endogenous (ce)RNA for miR-199a-5p, upregulated expression of its endogenous targets HIF-1a and inhibited its function. |
| Pubmed ID | 29115513 |
| Year | 2017 |
| Title | LncRNA PVT1 regulate expression of HIF1a via functioning as ceRNA for miR-199a-5p in non-small cell lung cancer under hypoxia. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |