Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, RNAi, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | cervical cancer tissues, cell lines (HeLa, SiHa, Ect1/E6E7) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 was up-regulated in cervical cancer tissue and cell lines. After transfecting PVT1 siRNA, the proliferation, migration and invasion of cervical cancer cells were markedly decreased. Bioinformatics analysis revealed that miR-424 was potentially targeted by PVT1, which was confirmed by dual-luciferase reporter assay. Finally, miR-424 lower-expression could recover the tumor-suppressive effects of PVT1 knockdown in cervical cancer cell lines. |
| Pubmed ID | 28276314 |
| Year | 2017 |
| Title | Long Non-Coding RNA PVT1 Facilitates Cervical Cancer Progression Via Negative Regulating of miR-424. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |