Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | gliomas tissues, cell lines (U87, U251 and HEK-293T) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 was up-regulated in glioma specimens and cell lines.Knockdown of PVT1 impaired the malignant behaviors of glioma cells via the suppression of proliferation,migration and invasion,as well as through promotion of apoptosis. Furthermore,PVT1 was identified to affect the glioma cells via binding to miR-190a-5p and miR-488-3p, which were down-regulated and played tumor suppressor roles in glioma cells. Over-expression of MEF2C up-regulated JAGGED1 by increasing the promoter activity of JAGGED1.Over-expression of PVT1 promotes multiple drug-resistance in gastric cancer. |
| Pubmed ID | 29501773 |
| Year | 2018 |
| Title | PVT1 regulates the malignant behaviors of human glioma cells by targeting miR-190a-5p and miR-488-3p. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |