Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blotting etc. |
| Sample | cell lines (MCF-7, BT474, ZR-75-1, SKBR3, MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 expression is upregulated in human breast cancer tissues and cell lines.And the elevation of PVT1 was correlated with poor prognosis in breast cancer patients. We also identified an interaction between SOX2 and PVT1, which promotes breast cancer growth and invasion through epithelial to mesenchymal transition. To further reveal the function of SOX2/ PVT1 in breast cancer, the MTT and invasion assay were performed through silencing of PVT1 or SOX2. We found that either knockdown PVT1 or blocking SOX2 can suppress breast cancer cell growth and invasion through inhibition of EMT. |
| Pubmed ID | 28882595 |
| Year | 2017 |
| Title | Upregulation of SOX2 activated LncRNA PVT1 expression promotes breast cancer cell growth and invasion |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |