Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | melanoma tissues, cell lines (M21, B16F10, MM200, MEL-RM, A375, A2058) |
| Expression Pattern | up-regulated |
| Function Description | Expression of PVT1 was significantly up-regulated in melanoma tissue and associated with poor prognosis.Overall,our study demonstrates the oncogenic role of PVT1 as a miR-26b sponge, possibly providing a novel therapeutic target for melanoma |
| Pubmed ID | 28409552 |
| Year | 2017 |
| Title | Long Noncoding RNA PVT1 Promotes Melanoma Progression Via Endogenous Sponging MiR-26b |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |