Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | small cell lung cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, RNAi, Cell proliferation assay, Cell migration and invasion assay etc. |
| Sample | SCLC tissues, cell lines (H446, H2227, 16HBE, BEAS-2B) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 expression was markedly higher in SCLC tissues and cell lines than in normal lung tissues and normal bronchial epithelial cell lines. High levels of PVT1 were positively associated with the status of clinical stage, lymph node metastasis, and distant metastasis in SCLC patients. Knocking down PVT1 expression significantly inhibited the SCLC cell migration and invasion in vitro. |
| Pubmed ID | 27904703 |
| Year | 2016 |
| Title | LncRNA PVT1 overexpression is a poor prognostic biomarker and regulates migration and invasion in small cell lung cancer. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for small cell lung cancer | OMIM COSMIC |