Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | cell lines (A549, 95D, HCC827, NCI-H1650) |
| Expression Pattern | up-regulated |
| Function Description | YY1 could directly bind to the promoter region of (long noncoding RNAplasmacytoma variant translocation 1 [lncRNA-PVT1]) and activated its transcription through the consensus YY1 motif. Knockdown of the expression of YY1 reduced cell proliferation in vivo, consistent with the results obtained from silencing the expression of YY1 in lung cancer cells. Collectively, our study showed a critical role of YY1 in the regulation of tumorigenesis, partly through its downstream target PVT1 |
| Pubmed ID | 28972861 |
| Year | 2017 |
| Title | Transcription Factor YY1 Modulates Lung Cancer Progression by Activating lncRNA-PVT1 |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |