Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RNAi etc. |
| Sample | cell lines (K562, TF-1, HL-60 and JJN3) |
| Expression Pattern | down-regulated |
| Function Description | Our results demonstrated that PVT1 knock-down results in c-Myc degradation, proliferation down-regulation, induction of apoptosis and G0/G1 arrest. Simultaneously, for the first time, we posited the relation between this oncogene with hTERT that reduced after PVT1 knock-down. Considering these results, long non-coding RNA PVT1 may be a potential option for targeted therapy in hematologic malignancies. |
| Pubmed ID | 29510227 |
| Year | 2018 |
| Title | Long non-coding RNA PVT1 as a novel candidate for targeted therapy in hematologic malignancies. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for leukemia | OMIM COSMIC |