Basic Information
| LncRNA/CircRNA Name | BDNF-AS |
| Synonyms | NA |
| Region | GRCh38_11:27506838-27698174 |
| Ensemble | ENSG00000245573 |
| Refseq | NR_002832 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oesophageal cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | oesophageal cancer tissues, cell lines (OE19, KYSE-70, KYSE-170, KYSE-180, OE33, Eca-109, TE-1 and TE-13) |
| Expression Pattern | down-regulated |
| Function Description | LncRNA BDNF-AS was remarkably down-regulated, while miR-214 was up-regulated in EC tissues and cells in comparison with normal tissues and cells. Overexpression of BDNF-AS significantly inhibited the abilities of cell proliferation, migration and invasion as well as the EMT processes of EC cells. The bioinformatics analysis and luciferase assay indicated that BDNF-AS could be directly bound by miR-214. Furthermore, overexpression of miR-214 and BDNF-AS exerted suppressive influence on EC cell multiplication, migration, invasion and EMT processes. LncRNA BDNF-AS restrained cell proliferation, migration, invasion and EMT processes in EC cells by targeting miR-214. |
| Pubmed ID | 29896888 |
| Year | 2018 |
| Title | LncRNA BDNF-AS Inhibits Proliferation, Migration, Invasion and EMT in Oesophageal Cancer Cells by Targeting miR-214 |
External Links
| Links for BDNF-AS | GenBank HGNC NONCODE |
| Links for oesophageal cancer | OMIM COSMIC |