Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | NA |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | glioma samples (grade II-IV) and adjacent non-tumor tissues, glioma cell lines U-87MG, U373MG, U251, SHG44, T98G and CHG-5, and human astrocyte normal cells HEB |
| Expression Pattern | up-regulated |
| Function Description | PVT1 expression in glioma was upregulated. In vitro, PVT1 silencing via transfection with si-PVT1 suppressed proliferation and invasion and induced G0/G1 phase arrest. Luciferase reporter assay revealed the association between miR-200a and the PVT1 3'-untranslated region. Furthermore, experiments examining both miR-200a and PVT1 indicated that miR-200a could reverse the effects of PVT1 on glioma cell phenotypes. |
| Pubmed ID | 30680011 |
| Year | 2019 |
| Title | Long non-coding RNA PVT1 promotes glioma cell proliferation and invasion by targeting miR-200a |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |