Basic Information
| LncRNA/CircRNA Name | BDNF-AS |
| Synonyms | NA |
| Region | GRCh38_11:27506838-27698174 |
| Ensemble | ENSG00000245573 |
| Refseq | NR_002832 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Microarray, RIP |
| Sample | glioblastoma tissues,cell lines |
| Expression Pattern | down-regulated |
| Function Description | In this study, we confirmed that lncRNA brain-derived neurotrophic factor antisense (BDNF-AS) was downregulated in glioblastoma tissues and cells, interacted and stabilized by polyadenylate-binding protein cytoplasmic 1 (PABPC1). |
| Pubmed ID | 32015336 |
| Year | 2020 |
| Title | PABPC1-induced stabilization of BDNF-AS inhibits malignant progression of glioblastoma cells through STAU1-mediated decay |
External Links
| Links for BDNF-AS | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |