Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, RNAi, other |
| Sample | TNBC tissues and cell lines(MDA-MB-231, MDA-BA-468, and BT549) |
| Expression Pattern | up-regulated |
| Function Description | Our results demonstrated that the mature adipogenic medium promoted the epithelial-mesenchymal transition, enhanced the cell viability and migration potential of TNBC cells. In addition, we proved that mature adipogenic medium affected the PVT1 expression and inhibition of the PVT1 disturbed the role of mature adipogenic medium in TNBC cells. Finally, we illustrated that repression of p21 restored the phenotype caused by PVT1 knockdown in TNBC cells treated with mature adipogenic medium. |
| Pubmed ID | 30371726 |
| Year | 2018 |
| Title | PVT1 Affects EMT and Cell Proliferation and Migration via Regulating p21 in Triple-Negative Breast Cancer Cells Cultured With Mature Adipogenic Medium |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |