Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | NA |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, RIP, Dual Luciferase Reporter Assay, Western blot |
| Sample | glioma tissues, cell lines(U87, SHG-44, U251, H4, HEB) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA PVT1 was highly expressed in human glioma tissues and significantly associated with WHO grade. There existed a regulatory relationship between lncRNA PVT1 and miR-128-3p. Overexpression of GREM1 promoted the proliferation and metastatic potential of glioma cells. Knockdown of LncRNA PVT1 Inhibited Glioma Cell Proliferation, Invasion, and Migration and Affected Cell Cycle and Apoptosis via Regulation of MiR-128-3p. |
| Pubmed ID | 30120709 |
| Year | 2018 |
| Title | LncRNA PVT1 Facilitates Tumorigenesis and Progression of Glioma via Regulation of MiR-128-3p/GREM1 Axis and BMP Signaling Pathway. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |