Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | NA |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | cell line (human AEL, AML M6) |
| Expression Pattern | up-regulated |
| Function Description | Plasmacytoma variant translocation 1 (PVT1) is a significantly upregulated lncRNA in AML. PVT1 inhibition could significantly decrease the viability of AEL cells, due to induction of apoptosis and necrosis. |
| Pubmed ID | 30141968 |
| Year | 2018 |
| Title | Knockdown of Long Noncoding RNA Plasmacytoma Variant Translocation 1 with Antisense Locked Nucleic Acid GapmeRs Exerts Tumor-Suppressive Functions in Human Acute Erythroleukemia Cells Through Downregulation of C-MYC Expression. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |