Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | NA |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal adenocarcinoma |
| ICD-0-3 | C15 |
| Methods | qRT-PCR , Western blot , RIP , in vitro knockdown etc. |
| Sample | EAC tumor tissues and normal esophageal tissues ,normal esophageal epithelial cell line HET-1A ,esophageal adenocarcinoma cancer cell lines (JHESO, OE19, FLO1, and SKGT-4) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 expression was up-regulated in EACs compared with paired BEs, and normal esophageal tissues. High expression of PVT1 was associated with poor differentiation, lymph node metastases, and shorter survival.Effective knockdown of PVT1 in EAC cells using PVT1 ASOs resulted in decreased cell proliferation, invasion, colony formation, tumor sphere formation, and reduced proportion of ALDH1A1+ cells.Most importantly, we found that targeting both PVT1 and YAP1 using their specific ASOs led to better antitumor activity in vitro and in vivo. |
| Pubmed ID | 31601234 |
| Year | 2019 |
| Title | LncRNA PVT1 Up-Regulation Is a Poor Prognosticator and Serves as a Therapeutic Target in Esophageal Adenocarcinoma |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for esophageal adenocarcinoma | OMIM COSMIC |