Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | NA |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pituitary adenoma |
| ICD-0-3 | C75.1 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | pituitary adenoma tissues and corresponding adjacent non-tumorous tissues ,human pituitary adenoma cell lines(GH3 and HP75), the human neuropile glial cell line HNPG? |
| Expression Pattern | up-regulated |
| Function Description | The PVT1 expressions were significantly enhanced in tissues of pituitary adenoma and cancer cells. Cell migration and proliferation were inhibited when the PVT1 gene was knocked down. Knockdown of PVT1 repressed the migration and EMT of pituitary adenoma cells. The PVT1 downregulation obviously blocked Wnt/?-catenin signaling pathway activity. PVT1 aggravated progression of pituitary adenoma through initiating the Wnt/?-catenin signaling pathway. |
| Pubmed ID | 31604907 |
| Year | 2019 |
| Title | Long Non-Coding RNA Plasmacytoma Variant Translocation 1 (PVT1) Enhances Proliferation, Migration, and Epithelial-Mesenchymal Transition (EMT) of Pituitary Adenoma Cells by Activating ?-Catenin, c-Myc, and Cyclin D1 Expression |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for pituitary adenoma | OMIM COSMIC |