Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | NA |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | RCC (all ccRCC) tissues and adjacent normal tissues ,normal renal epithelial cells (HK-2) and renal cancer cell lines (A498, 786-O, ACHN and Caki-1)? |
| Expression Pattern | up-regulated |
| Function Description | PVT1 was upregulated in RCC tissues compared with the adjacent normal tissues.PVT1 expression was closely correlated with TNM stage, Fuhrman grade, lymph node metastasis and tumor size.High expression of PVT1 was significantly associated with poor overall survival.Silencing of PVT1 significantly repressed cell viability, induced apoptosis and inhibited cell migration and invasion in vitro.Furthermore, miR-16-5p was a target of PVT1. Silencing of miR-16-5p mostly reversed the regulatory effects on RCC cells induced by downregulation of PVT1. |
| Pubmed ID | 31040699 |
| Year | 2019 |
| Title | LncRNA PVT1 Promotes Proliferation, Invasion and Epithelial-Mesenchymal Transition of Renal Cell Carcinoma Cells Through Downregulation of miR-16-5p |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |