Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | NA |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | colon epithelial cell line CCD 841 CoN ,human CRC cell lines(112 HT-29, LoVo, SW480, SW620 and HCT-116) |
| Expression Pattern | up-regulated |
| Function Description | IRS1 and lncRNA PVT1 were highly expressed in CRC.PVT1 was primarily located in the cytoplasm.PVT1 to be a competitive endogenous RNA (ceRNA) against miR-214-3p, and IRS1 was found to be a target of miR-214-3p.The expression pattern of lncRNA PVT1, miR-214-3p, IRS1, phosphoinositide 3-kinase (PI3K), and Akt was characterized in response to lncRNA PVT1 silencing or miR-214-3p upregulation. Meanwhile, their regulatory effects on cell proliferation, invasion, and apoptosis were detected in CRC cells.With increased levels of miR-214-3p and decreased levels of lncRNA PVT1 in CRC cells, the expression of PI3K and Akt was reduced, and consequently, the cell apoptosis was stimulated and cell proliferation and invasion were suppressed. |
| Pubmed ID | 31125260 |
| Year | 2019 |
| Title | Knockdown of Long Noncoding RNA PVT1 Suppresses Cell Proliferation and Invasion of Colorectal Cancer via Upregulation of microRNA-214-3p |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |