Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | plasmacytoma variant translocation 1 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | QRT-PCR, Western blot, Dual Luciferase Reporter Assay, RIP |
| Sample | glioma tissue,cell lines U87, U251, HS683, T98MG, and normal human cell line HEB |
| Expression Pattern | up-regulated |
| Function Description | Over-expressing PVT1 increased cell proliferation, invasion, and aerobic glycolysis, while inhibiting PVT1 yielded opposite outcome. Dual-Luciferase reporter assay confirmed that PVT1 could target miR-140-5p. Functional analysis showed that over-expression of miR-140-5p inhibited proliferation, invasion, and aerobic glycolysis in glioma cells. Rescue experiment found that the inhibitory effect of miR-140-5p could be eliminated by up-regulating PVT1 expression. |
| Pubmed ID | 31957841 |
| Year | 2020 |
| Title | Long Non-Coding RNA PVT1 Regulates Glioma Proliferation, Invasion, and Aerobic Glycolysis via miR-140-5p |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |