Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | NA |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | pancreatic cancer tissues, cell lines (PANC1, PaTu8988 and SW1990) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 promoted the growth and the epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. We first determined that PVT1 was upregulated in pancreatic cancer tissues compared with adjacent normal tissues. Knockdown of PVT1 inhibited viability, adhesion, migration and invasion. Furthermore, PVT1 knockdown reduced the expression of mesenchymal markers including Snail, Slug, ?-catenin, N-cadherin and vimentin, while it increased epithelial marker expression of E-cadherin. Finally, knockdown of PVT1 inhibited the TGF-?/Smad signaling, including p-Smad2/3 and TGF-?1 but enhanced the expression of Smad4. In contrast, overexpression of PVT1 reversed the process. |
| Pubmed ID | 29845201 |
| Year | 2018 |
| Title | Long Non-coding RNA PVT1 Promotes Epithelial-mesenchymal Transition via the TGF-?/Smad Pathway in Pancreatic Cancer Cells |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |