Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | NA |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot |
| Sample | OS tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | ALKBH5-mediated PVT1 upregulation promoted the OS cell proliferation in vitro and tumor growth in vivo. |
| Pubmed ID | 32021563 |
| Year | 2020 |
| Title | ALKBH5-mediated m 6 A demethylation of?lncRNA PVT1 plays an oncogenic role in?osteosarcoma |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |