Basic Information
| LncRNA/CircRNA Name | PURPL |
| Synonyms | NA |
| Region | GRCh38_5:27472292-27496401 |
| Ensemble | ENSG00000250337 |
| Refseq | NR_038848 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | liver cancer tissues and paracancerous tissues ,liver cancer cell lines(HepG2, Huh7,HCCLM3, SK-hep1, and PLC/PRF/5 ,normal liver cell line, L02 |
| Expression Pattern | up-regulated |
| Function Description | PURPL was significantly upregulated in liver cancer tissues compared with in paracancerous tissues, and was associated with tumor differentiation stage and tumor size.PURPL was also upregulated in various liver cancer cell lines. Silencing of PURPL inhibited liver cancer cells proliferation, blocked cell cycle progression, and promoted apoptosis.PURPL expression was negatively correlated with p53 mRNA expression. |
| Pubmed ID | 31059022 |
| Year | 2019 |
| Title | Long noncoding RNA PURPL promotes cell proliferation in liver cancer by regulating p53 |
External Links
| Links for PURPL | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |